Magnetic resonance imaging of transplanted stem cell fate in stroke

Abstract

Nowadays, scientific c findings in the field of regeneration of nervous system have revealed the possibility of stem cell based therapies for damaged brain tissue related disorders like stroke. Furthermore, to achieve desirable outcomes from cellular therapies, one needs to monitor the migration, engraftment, viability, and also functional fate of transplanted stem cells. Magnetic resonance imaging is an extremely versatile technique for this purpose, which has been broadly used to study stroke and assessment of therapeutic role of stem cells. In this review we searched in PubMed search engine by using following keywords; “Stem Cellsâ€, “Cell Trackingâ€, “Strokeâ€,“Stem Cell Transplantationâ€, “Nanoparticlesâ€, and “Magnetic Resonance Imaging†as entry terms and based on the mentioned key words, the search period was set from 1976 to 2012. The main purpose of this article is describing various advantages of molecular and magnetic resonance imaging of stem cells, with focus on translation of stem cell research to clinical research.

Key words: Cell fate, cell tracking, magnetic resonance imaging, nanoparticle, stem cells, stroke, tracking