The Most Common Bacterial Agents and Their Antibiotic Sensitivity in ICU Patients of Al-Zahra Hospital in Isfahan

Abstract

Background: There are many reports about nosocomial infections in ICU patients, their antibiotic resistance and the necessity of combination therapy with two or more different antibiotics. This study was designed to find the predominant pathogens and their antimicrobial resistance in a University hospital intensive care unit. Methods: We obtained samples from patients who had no signs and symptoms of infection on admission in ICU but showed infection signs at least after 48 hours. Cultures were obtained and antibiogram tests were done. Thereafter appropriate Results: About 40 percent of ICU patients were infected through their hospitalization. Urinary tract infection (UTI), respiratory, blood, and CNS infections were the most common infections. Gram-negative rods were including E-coli, Kelebsiella, pseudomonas and enterobacters, Gram-positive pathogens (staphylococcus epidermidis and S-aureus) were reported. Most of pathogens had resistance not only to common antibiotics but also to new generation ones. In most cases, empirical therapy had not been scaled down to definitive regimen with optimal activity, although the pathogen had been isolated and its antimicrobial sensitivities were identified. Conclusion: Widespread use of antimicrobial agents without any precaution is responsible for antibiotic resistance. This shows the necessity of prevention of infections with use of proper antibiotics.
Keywords: ICU, Bacterial, Resistance.