Identification of homogeneously staining regions in leukemia patients

Mohammad Heydarian Moghadam, Abolfazl Movafagh, MirDavood Omrani, Kiandokht Ghanati, Mehrdad Hashemi, Farhikhteh Poursafavi, Hossein Darvish, Davood Zare Abdolahi, Milad Gholami, Mohammad Reza Heidari Rostamy, Shamsi Safari, Leyla HaghNejad, Reyhaneh Darehgazani, Niloofar Safavi Naeini, Mehdi Ghandehari Motlagh, Davar Amani


  • Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leukemia without maturation (AML-M1), aged 23-year-old female, and the other with chronic myelogenous leukemia (CML)-blast crisis, a 28-year-old female associated with double minute chromosomes. Most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.
  • Key words: AML, cancer, chronic myelogenous leukemia, homogeneously staining regions dmin, HSRs/DMs, HSRs, Iran,incidence, leukemia, new case

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