THE COMPARATIVE EVALUATION BETWEEN EPINEPHRINE AND DOPAMINE ON BLOOD PRESSURE DURING WEANING FROM CPB
Abstract
Background. Special management and intropic drugs are required for homodynamic stability due to weaning of cardiopulmonary bypass (CPB). The inotropic drugs in this manner are very controversial. However, there is a little study about the choice inotropic. The porpuse of this study is evaluation of epinephrine and dopamine effect on the mean arterial pressure (MAP) during pump weaning.
Methods. This clinical trial study was done on the 124 patients which were divided into two groups E (Epinephrine) and D (Dopamine) randomly. Epinephrine infusion (0.05 mg/kg/min) was started in group E (n=56) due to unclamping of the aorta (zero time) and dopamine (8 mg/kg/min) in group D (n=68) samely. MAP was recorded in 0, 10, 20, 30, 60, 120 and 360 minutes. The partial time (the duration time between unclamping and complete weaning of the pump) was the determined in two groups.
Findings. The mean percentage rising of MAP was 69.9 and 27.3 in group E and D respectively (P<0.01). Partial time was 49 and 46 minutes in group E and D respectively (P>0.05).
Conclusion. Epinephrine increase MAP more than dopamine and prevents of hypotension during pump weaning. Nevertheless, epinephrine could not reduce partial time because many other factors except stabilizing of MAP have important role in the weaning.
Methods. This clinical trial study was done on the 124 patients which were divided into two groups E (Epinephrine) and D (Dopamine) randomly. Epinephrine infusion (0.05 mg/kg/min) was started in group E (n=56) due to unclamping of the aorta (zero time) and dopamine (8 mg/kg/min) in group D (n=68) samely. MAP was recorded in 0, 10, 20, 30, 60, 120 and 360 minutes. The partial time (the duration time between unclamping and complete weaning of the pump) was the determined in two groups.
Findings. The mean percentage rising of MAP was 69.9 and 27.3 in group E and D respectively (P<0.01). Partial time was 49 and 46 minutes in group E and D respectively (P>0.05).
Conclusion. Epinephrine increase MAP more than dopamine and prevents of hypotension during pump weaning. Nevertheless, epinephrine could not reduce partial time because many other factors except stabilizing of MAP have important role in the weaning.
Keywords
Cardiopulmonary Bypass, Epinephrine, Dopamine, Cardiovascular Surgery