COMPARING EFFECTIVENESS OF ORAL AND INTRANASAL MIDAZOLAM FOR PREMEDITATION IN CHILDREN
Abstract
Background. Preoperative evaluation and psychological preparation is important before anesthesia. Children are very dependent to their parents, specially before 5 years. Anesthesiologist must administer anxiolytic and sedative drugs before separation from parents as premeditation. The aim of this study is comparison survey on effect of oral midazolam and intranasal midazolam in children 1 to 5 years as premeditation.
Methods. In a clinical trial study performed through first half of 1377 at St. Alzahra Center (Isfahan University of Medicine), sixty healthy children in first class of ASA who had non gastrointestinal elective surgery were studied. Group one consisted of thirty children who received intravenous form midazolam (0.5 mg/kg) with fruit juice orally 45 to 60 minutes before operation. Group 2 consisted of thirty children who received midazolam (IV form) 0.2 mg/kg intranasally 15 minutes before operation.
Findings. Anxiety was less in first group during administration of drug. Forty four percent were quiet in this group (P < 0.005). Seventy six percent of children who well accepted the drug, were in the first group (P < 0.005). There was no significant statistical difference between two groups in other aspects of study.
Conclusion. Oral administration of midazolam has better acceptance in children than intranasal with less anxiety.
Methods. In a clinical trial study performed through first half of 1377 at St. Alzahra Center (Isfahan University of Medicine), sixty healthy children in first class of ASA who had non gastrointestinal elective surgery were studied. Group one consisted of thirty children who received intravenous form midazolam (0.5 mg/kg) with fruit juice orally 45 to 60 minutes before operation. Group 2 consisted of thirty children who received midazolam (IV form) 0.2 mg/kg intranasally 15 minutes before operation.
Findings. Anxiety was less in first group during administration of drug. Forty four percent were quiet in this group (P < 0.005). Seventy six percent of children who well accepted the drug, were in the first group (P < 0.005). There was no significant statistical difference between two groups in other aspects of study.
Conclusion. Oral administration of midazolam has better acceptance in children than intranasal with less anxiety.
Keywords
Premeditation, Midazolam, Drug Administration -Intranasal -Oral, Pediatric Anesthesia