IMPLANTATION OF AN IRANIAN MADE HYDROXYAPATITE IN RABIT"S ORBIT: DOES IT WORK EFFECTIVELY?
Abstract
Introduction. Good results of foreign made Hydroxyapatite in human orbit, expensive American and Europian made hydroxyapatites, the possibility to make this material from coral by hydrothermal method and good source of coral in Persian Gulf made us start this study.
Methods. The left eye of 21 male rabits weighing 200-270 grams were enucleated and implanted by 14mm coralline spheres being covered by preserved rabits sclera (11 with pure coral and 10 with Iranian made hydroxyapatite). The implants were removed for pathologic study after an average time of 79.4 days of clinical evaluation. The type of coral was acropora and the hydrothermal Ion exchange form carbonate to phosphate was performed in chemistry department of Isfahan University.
Results. No evidence of extrusion was seen in implants. Exposure phenomena was seen 55 and 12 percent in coralline and hydroxyapatite implantation, respectively (P < 0.05). Tissue inflammation was detect 89 and 25 percent of coralline and hydroxyapatite implantation, respectively (P < 0.05).
Discussion. The tissue tolerance of rabits orbit to Iranian made hydroxyapatite was almost fair and it"s use in human"s orbit could probably be tried safely. Orbital implantation of natural coral in rabits" orbit is accompanied by moderate to sever tissue inflammatory response and tissue necrosis, creating more clinical complications.
Methods. The left eye of 21 male rabits weighing 200-270 grams were enucleated and implanted by 14mm coralline spheres being covered by preserved rabits sclera (11 with pure coral and 10 with Iranian made hydroxyapatite). The implants were removed for pathologic study after an average time of 79.4 days of clinical evaluation. The type of coral was acropora and the hydrothermal Ion exchange form carbonate to phosphate was performed in chemistry department of Isfahan University.
Results. No evidence of extrusion was seen in implants. Exposure phenomena was seen 55 and 12 percent in coralline and hydroxyapatite implantation, respectively (P < 0.05). Tissue inflammation was detect 89 and 25 percent of coralline and hydroxyapatite implantation, respectively (P < 0.05).
Discussion. The tissue tolerance of rabits orbit to Iranian made hydroxyapatite was almost fair and it"s use in human"s orbit could probably be tried safely. Orbital implantation of natural coral in rabits" orbit is accompanied by moderate to sever tissue inflammatory response and tissue necrosis, creating more clinical complications.
Keywords
Hydroxyapatite, Coral, Orbit implantation, Animal