THE EFFICACY OF HEPATITIS B VACCINE IN HEMOPHILIC PATIENTS WITH HEPATITIS C VIRAL INFECTION
Abstract
Introduction: Some studies suggest that immunogenicity of HBV vaccine is low in HCV positive persons. This study is performed in hemophilic patients (which many of them are HCV POSITNE) for rule out or rule in of this subject.
Methods: In this analytic field trial, 33 HCV negative and 37 HCV positive hemophilic patients were randomly selected. There was not more than 3 years from the last vaccine (3 dose, each dose 40 U.G.). Sampling for HBS antibody titer was done. Results were annaunced as: Negative < 10 MIU), low positive (10-100 MIU),and high positive ( > 100 MIU).
Results: Non response was observed in 3.33 (%9) of HCV negative persons and in 2.37 (%5.4) of HCV positive persons (PV = 0.446).P.value was not significant.
Discussion: In this study, there is not difference in antibody response between two groups. This may be due to higher dose of vaccine in this study.
Methods: In this analytic field trial, 33 HCV negative and 37 HCV positive hemophilic patients were randomly selected. There was not more than 3 years from the last vaccine (3 dose, each dose 40 U.G.). Sampling for HBS antibody titer was done. Results were annaunced as: Negative < 10 MIU), low positive (10-100 MIU),and high positive ( > 100 MIU).
Results: Non response was observed in 3.33 (%9) of HCV negative persons and in 2.37 (%5.4) of HCV positive persons (PV = 0.446).P.value was not significant.
Discussion: In this study, there is not difference in antibody response between two groups. This may be due to higher dose of vaccine in this study.
Keywords
Hepatitis B, Hepatitis C, Hepatitis B vaccine, HBS Ab, HBS Ag, Hemophilia