Association between physical activity and serum liver aminotransferases in Southwestern Iran: A Cross?sectional study

Sajad Badiei, Seyed Jalal Hashemi, Abdolrahim Masjedizadeh, Jalal Sayyah, Zahra Mohammadi, Sanam Hariri, Farnaz Hashemi, Zahra Rahimi, Leila Danehchin, Farhad Abolnezhadian, Reza Malihi, Yousef Paridar, Seyyed Ali Mard, Bahman Cheraghian, Hossein Poustchi, Ali Akbar Shayesteh


Background: The main aim of the present study is to investigate the independent association objectively measured level of physical activity (PA) and serum concentration of liver aminotransferases (alanine  minotransferase [ALT] and aspartate aminotransferase [AST]) among  eemingly healthy individuals. Materials and Methods: The current  econdary study was conducted in the framework of Khuzestan Comprehensive Health Study, a large population?based multicentric cross?sectional study, conducted between 2016 and 2019 on 18,966 individuals living in Khuzestan province, southwestern Iran. International PA Questionnaire was used for evaluating PA levels, and participants were divided into three groups: low, moderate, and high PA, and ALT and AST were compared between these groups. Results: The mean ±  tandard deviation age of participants was 38.65 ± 11.40 years. The  ajority of participants were female (71%). The mean concentration of ALT in total sample was 18.22 ± 13.06 (male: 23.65 ± 16.26 and female:  5.57 ± 10.06), while the mean concentration of ALT in total sample was 19.61 ± 8.40 (male: 22.44 ± 10.03 and female: 18.23 ± 7.08). A  tatistically significant inverse correlation was found between AST (r =  0.08, P = 0.02) and ALT (r = ?0.038, P < 0.001) with total PA score. The mean concentration of ALT was 19.96 ± 13.63 in people with low PA, 17.62 ± 12.31 with moderate PA, and 18.12 ± 13.47 with high PA (P <  .001). The mean concentration of AST in total sample was 20.37 ± 8.85 in people with low PA, 19.21 ± 8.83 with moderate PA, and 19.75 ± 8.85 with high PA (P < 0.001). The difference between people in different  evels of PA in terms of mean concentration of AST was remained  ignificant (P = 0.003); however, the difference for ALT was not remained significant after adjusting potential confounders. Conclusion: The current  tudy based on large sample showed that PA had a statistically negative  ssociation with the concentration of liver aminotransferases in the  eemingly healthy individuals; however, the observed associations were weak. People in the lowest levels of PA had the highest levels of ALT and  ST.


Alanine aminotransferase, aspartate aminotransferase, liver aminotransferase, physical activity

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