Body composition and serum levels of matrix metalloproteinase?9, adiponectin and AMP?activated protein kinase in breast cancer survivors

Zeinab Babaei, Hadi Parsian, Bahare Korani, Amrollah Mostafazadeh, Dariush Moslemi

Abstract


Background: Available data suggest that obesity is related to changes in the several adipocyte?derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation  etween obesity with metalloproteinase?9 (MMP?9), adiponectin and adiponectin and AMP?activated protein kinase (AMPK) levels by comparing serum levels of MMP?9, AMPK in normal weight and obese breast cancer survivors. Materials and Methods: In this cross?sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5?25 kg/m2) and 30 obese breast cancer survivors (BMI ?30 kg/m2) were investigated.
Anthropometric parameters and serum levels of MMP?9, adiponectin, and AMPK were compared between the two groups.

Results: No differences were detected in the serum levels of MMP?9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP?9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05).

Conclusion: We found that there was a lack of correlation between obesity measures and serum levels of MMP?9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP?9 do not change in obesity state.


Keywords


Adiponectin, AMP?activated protein kinase, breast cancer, matrix metalloproteinase?9, obesity

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