Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis

Marcella Martinelli, Luca Scapoli, Angela Maria Grazia Pacilli, Paolo Carbonara, Ambra Girardi, Gabriella Mattei, Maria Teresa Rodia, Rossella Solmi


Background: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. Materials and Methods: We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins. Results: No evidence of association was detected. Conclusion: There  are 50 known  MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.

Key words: Idiopathic pulmonary fibrosis, multidrug resistance 1 gene, polymorphism

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