Flecainide associated torsade de pointes: A potential case of reverse use dependence

Abstract

Flecainide has been known to cause torsades de pointes (TdP) in patients with structural heart disease and its mechanism has been attributed to use-dependency. We present a patient with flecainide-induced TdP in the absence of any other precipitating factors.This case highlights potential reverse use dependence associated with flecainide resulting in TdP.


Key words: Arrhythmias, clinical electrophysiology, drugs, electrophysiology, receptor pharmacology