Diffuse Intracranial Calcification in Hypoparathyroidisem due to Metastatic Infiltration of Parathyroid Gland

Firooz Salehpour, Javad Aghazadeh, Moslem Shakeri, Ata Mahdkhah, Ali Baradaran Bagheri, Aidin Kazem Poor Azar

Abstract


Background: To report a case of diffuse intracranial calcification in hyperparathyroidism due to metastatic infiltration of parathyroid gland.

Case presentation: We report a 53 year-old man that his significant clinical presentation was seizure, and resting tremor .and after investigations hyperparathyroidism confirmed basis on his laboratory data. He had decreased PTH & calcium & increased phosphorus .and ultimately the diagnosis of hyperparathyroidism due to metastatic infiltration stabilized. The source of his metastases was colorectal adenocarcinoma .his brain CT images revealed diffuse intracranial calcification in basal ganglia and subcortical white matter and cerebellum intracranial calcification is a common finding in clinical practice but diffuse intracranial calcification is a rare finding.

Conclusion: Hypoparathyroidism is well known to cause basal ganglia calcification in most of the patients. But diffuse intracranial calcification caused by hyperparathyroidism is rare.


Keywords


Diffuse intracranial calcification; hypocalcemia; hypoparathyroidisem