Adiponectin gene polymorphisms and susceptibility to atherosclerosis: A meta‑analysis

Abstract

• Previous studies have inspected the associations between Adiponectin (ADIPOQ) 276G/T polymorphisms and atherosclerosis, but the results are inconclusive. The aim of this study was to explore the relationship between polymorphism +276 G > T (rs1501299) in ADIPOQ and atherosclerosis. A widespread search was directed to identify all studies on the association of ADIPOQ 276G/T polymorphism with atherosclerosis risk. The fixed effect pooled measures according to odds ratio (OR) and 95% confidence interval (CI) were calculated in the meta-analysis. Heterogeneity among studies was evaluated using Q test and the I². Publication bias was estimated using modified Egger’s linear regression test and Fuunel plot. Nine studies regarding the associations between the ADIPOQ 276G/T polymorphism and atherosclerosis risk were enrolled in this meta-analysis, including 1959 cases and 3739 controls. The 276G/T polymorphism was not significantly associated with atherosclerosis, yielding pooled ORs of 0.925 (95% CI: 0.728-1.178) and 0.921 (95% CI: 0.804-1.054), for TT versus GG, and TG versus GG, respectively. Significant between-study heterogeneity was not found in our meta-analysis. Furthermore there was no evidence of publication bias in the meta-analysis. The present meta-analysis showed that there is no association between ADIPOQ 276G/T polymorphism and atherosclerosis. High quality studies are still needed to add for more investigation of the association between ADIPOQ 276G/T polymorphisms and atherosclerosis.
• Key words: Adiponectin, atherosclerosis, gene, meta‑analysis, polymorphism