Bone turnover markers in epileptic patients under chronic valproate therapy

Mohammad Zare, Mohammad Reza Aghaye Ghazvini, Maseumeh Dashti, Mohammad Reza Najafi, Amir Mansour Alavi Naeini


  • Background: Th e eff ects of chronic valproic acid administration on bone health have been a matter of concern and controversy.In this study, the bone status following valproate intake was assessed by using several bone-related biochemical markers.
  • Materials and Methods: In this case-control study, 62 epileptic patients and 40 age- and gender-matched controls were enrolled. The patients had been under chronic valproate therapy (758 ± 29 mg/day) for at least the past 6 months, without any vitamin D/or calcium supplementation. Serum markers of bone turnover (carboxy-terminal telopeptide of type I collagen (CTX) and bone-specifi c alkaline phosphatase [BALP]), calcium, phosphorus, total alkaline phosphatase, and parathyroid hormone levels were measured in both groups.
  • Results: The markers of bone turnover as well as other measured bone biochemical parameters did not statistically differ between the two groups.
  • Conclusion: Valproate therapy at the mentioned doses does not seem to change bone turnover in adult epileptic patients.
  • Key words: Bone turnover markers, epilepsy, valproate sodium

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