The relationship between serum levels of vitamin D and migraine

Abstract

• Background: Migraine is common worldwide. In recent years, vitamin D deficiency has been determined as a global health problem. A few studies have shown inverse relationship between serum vitamin D levels and headache. Thus, in this study, we assessed relationship between serum vitamin D levels with migraine.
• Materials and Methods: The present study was a cross-sectional. Seventy-six migraine patients aged 10–61 years were included. The multiple linear regression was used to show association between serum 25-0H-D3 and migraine. Adjustments were performed for age, sex, waist circumference, body mass index (BMI), number of chronic diseases, and education level.
• Results: The positive weak relationship was observed between serum vitamin D and headache diary result (P=0.042, r=0.19). But, no significant relationship was observed between serum vitamin D and migraine severity (P=0.741).
• Conclusion: High levels of serum 25-OH-D3 was related to higher headache diary result. After adjustment for confounding variables, this significant association remained. No significant relationship was shown between serum vitamin D and migraine severity.
• Keywords: Migraine, relationship, vitamin D