Urotensin-II and endothelin-I levels after contrast media administration in patients undergoing percutaneous coronary interventions

Turgay Ulas, Hakan Buyukhatipoglu, Mehmet S. Dal, Idris Kirhan, Zekeriya Kaya, Mehmet E. Demir, Irfan Tursun, Mehmet A. Eren, Timucin Aydogan, Yusuf Sezen, Nurten Aksoy


  • Background: Contrast induced kidney injury is an acute renal dysfunction that is secondary to the administration of radio contrast media. The purpose of this study was to evaluate the levels of urotensin-II (UT-II) and endothelin-I (ET-I) after contrast media administration in patients undergoing percutaneous coronary interventions.
  • Materials and Methods: In this prospective cohort study, we evaluated 78 patients with coronary artery disease who were scheduled for and ultimately underwent percutaneous coronary interventions. As a contrast material, nonionic contrast media was used in various amounts (70-480 mL). Blood and urine samples were obtained to measure U-II, ET-I just before and at the twenty-fourth hour of percutaneous coronary interventions.
  • Results: Compared to baseline, twenty-fourth hour creatinine levels were significantly increased (P < 0.001). The twenty-fourth hour serum and urine levels of both UT-II and ET-I were also significantly increased compared to baseline (P < 0.001 for all) and 24th hour serum and urine UT-II (r = 0.322, P = 0.004; r = 0.302, P = 0.007 respectively), ET-I (r = 0.511, P < 0.001; r = 0.266, P = 0.019 respectively) levels were significantly correlated with the amount of contrast media.
  • Conclusion: Our study indicates that; increased UT-II and ET-I levels seem to be a consequence of hazardous effects of contrast media on blood vessels and the kidney.
  • Key words: Acute kidney injury, contrast media, coronary angiography, endothelin-I, urotensin-II

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