Pulmonary arterial hypertension and pregnancy

Demet Terek, Meral Kayikcioglu, Hakan Kultursay, Mete Ergenoglu, Mehmet Yalaz, Oktay Musayev, Nesrin Mogulkoc, Ilkben Gunusen, Mete Akisu, Nilgun Kultursay


  • This is the case report of a pregnant woman who refused pregnancy termination when diagnosed with pulmonary arterial hypertension (PAH) functional class 2–3 at the 24th week of gestation and of her newborn. A pregnant woman with PAH functional class 2–3 was treated with inhaled prostacyclin analog (iloprost), oral sildenafil, oxygen, and low molecular weight heparin. She delivered at 32nd week by Cesarean section. The infant required oxygen up to 36th week postconceptional age and had a short steroid treatment. The mother needed close cardiovascular monitorization, intensive oxygen and pulmonary vasodilator therapy for 2 months and was discharged with oxygen and oral iloprost treatment. A multidisciplinary approach together with pulmonary vasodilator therapy may be succesful in such a high-risk pregnant woman.
  • Key words: Iloprost, newborn, pregnancy, pulmonary hypertension, sildenafil, survival, therapy

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