Different measurements of the obesity, adiponectin and coronary heart disease: a single-center study from Isfahan

Abstract

• Background: Adipose tissue as an endocrine organ secretes adiponectin that is a cardiovascular atherosclerosis-modulating factor. However, some studies showed that adiponectin reduces obesity. In the present study, adiponectin association with body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) and subcutaneous visceral tissue (SAT) as different measurements of obesity were evaluated in patients with  coronary heart disease (CHD).
• Materials and Methods: Sixty-eight patients with CHD were chosen using simple random sampling. Body weight, height, WC and blood pressure were measured. Fasting blood samples were taken to assess fasting blood sugar, total cholesterol, triglyceride, low and high-density lipoproteins cholesterol. Patients underwent an abdominal computerized scan (CTS) to detect VAT and SAT. Linear regression test used to assess the relation of different measurements of the obesity with adiponectin adjusting for age, sex, hypertension, dyslipidemia, and diabetes mellitus.
• Results: The mean age of the study population was 50.5 ± 7.0. Females were 67.6% of study population. Multivariate analyses showed the inverse association of waist-to-height ratio (WHtR) (β = -0.25, p = 0.03), WC (β = -0.24, p = 0.24) and visceral fat (β = -0.32, p = 0.01) with adiponectin.
• Conclusions: WC and WHtR are simple proxy measures of obesity that better showed adverse metabolic effect of visceral fat in patients with CHD.
• Key Words: Adiponectin, Coronary Heart Disease, Obesity, Intra-abdominal Fat, Waist Circumference, Waist-to-height Ratio