The effect of Consanguineous Marriages on Congenital Malformation

A Mehrabi Kushki, B Zeyghami


Background: Consanguinity has been a long-standing social habit among some of Iranians. The estimation of consanguinity ratios in different parts of Iran ranged from 30 to 85%. This study aimed to delineating the role of consanguinity on congenital malformations in Khominishahr rural population, Isfahan, Iran.
Methods: In a case-control study, 518 malformed population (case group) and 518 normal subjects (control group) were randomly selected from khominishahr rural population, from July to November, 2003.
Results: The frequency of consanguinity of parent’s was 59.7% in case group and 31.5% in control group. This different was statistically significant (p < 0.001).
Conclusion: Family history of congenital malformation may play an important role in the high rates of congenital malformation.
Key words: Consanguinity, Congenital Malformations

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