Effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats

Parham Reisi, Hojjatallah Alaei, Shirin Babri, Mohammad Reza Sharifi, Gisue Mohaddes, Elaheh Soleimannejad, Bahman Rashidi

Abstract


  • BACKGROUND: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats.
  • METHODS: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated.
  • RESULTS: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups.
  • CONCLUSIONS: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
  • KEYWORDS: Diabetes, Glutamate, GABA, Dentate Gyrus, Treadmill Running, Microdialysis, Hippocampus, Streptozotocin.

Keywords


Diabetes; Glutamate; GABA; Dentate gyrus; Treadmill running, Microdialysis, Hippocampus, Streptozotocin.

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