THE EFFECT OF FLUOROCARBON ARTIFICIAL BLOOD (FC-34) IN ACUTE VASOGENIC BRAIN EDEMA
Abstract
Background. Oxygen transport to tissue after an acute ischemia is strongly important. Fluorocarbon liquids are able to facilitated the oxygen transport. An animal experiment was designed to study the effect of FC-34 in acute brain ischemia.
Methods. The left common carotid arteries were ligated in three groups of anesthetized animals for 30 minutes to obtain acute brain edema. The animals were subjected to received 15 ml/kg saline (group 1), 10% monitol (group 2) or FC-43 (group 3). All animals were recovered, and they monitored for two weeks. The electrolytes, BUN, and creatinine were measured before (all animals) and after two weeks (survived animals). Pathological investigation was obtained by light and electron microscope via pathological process.
Findings. The group 1 animals were died during first five days, but one and four animals were survived by two weeks in groups 2 & 3 respectively (P < 0.05). The pathological determinations indicate less cellular damages in group 3. No significant differences were detected in potassium, calcium, BUN, and creatinine before and after the experiment.
Conclusion. The particle size and oxygen solubility in FC-43 is the major factors for better oxygen transport in ischem
Methods. The left common carotid arteries were ligated in three groups of anesthetized animals for 30 minutes to obtain acute brain edema. The animals were subjected to received 15 ml/kg saline (group 1), 10% monitol (group 2) or FC-43 (group 3). All animals were recovered, and they monitored for two weeks. The electrolytes, BUN, and creatinine were measured before (all animals) and after two weeks (survived animals). Pathological investigation was obtained by light and electron microscope via pathological process.
Findings. The group 1 animals were died during first five days, but one and four animals were survived by two weeks in groups 2 & 3 respectively (P < 0.05). The pathological determinations indicate less cellular damages in group 3. No significant differences were detected in potassium, calcium, BUN, and creatinine before and after the experiment.
Conclusion. The particle size and oxygen solubility in FC-43 is the major factors for better oxygen transport in ischem
Keywords
Cerebral Edeme -Vasogenic, Fluorocarbon, Experimental Study