ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATIONS BY MAGNESIUM SULPHATE
Abstract
Background. Laryngoscopy and endotracheal intabation my produce adverse homodynamic effects such as hypertension and tachycardia. Magnesium has direct vasodilating properties on coronary arteries and inhibits catecholamine release, that attenuating the homodynamic effects during endotracheal intubations.
Methods. This randomized, double blind study compared the effects of magnesium sulphate with lidocaine for attenuating of pressor response to tracheal intubations in 120 patients undergoing general anesthesia for cataract surgery. We have studied the effect of pretreatment with magnesium sulphate 0.1 mg/kg (50 percent) or 1.5 mg/kg lodocaine on this pressor response.
Findings. There were no significant differences between two groups with respect preinduction of heart rate, mean arterial pressure, sex and age (P > 0.05). A combined analysis showed that the 0.1ml/kg magnesium sulphate were significantly (P < 0.05) better than 1.5mg/kg lidocaine in attenuating pressur response to tracheal intubation.
Conclusion. Intravenous magnesium sulphate is safe and effective at preventing postoperative tachycardia and hypertension and it is better than lidocaine.
Methods. This randomized, double blind study compared the effects of magnesium sulphate with lidocaine for attenuating of pressor response to tracheal intubations in 120 patients undergoing general anesthesia for cataract surgery. We have studied the effect of pretreatment with magnesium sulphate 0.1 mg/kg (50 percent) or 1.5 mg/kg lodocaine on this pressor response.
Findings. There were no significant differences between two groups with respect preinduction of heart rate, mean arterial pressure, sex and age (P > 0.05). A combined analysis showed that the 0.1ml/kg magnesium sulphate were significantly (P < 0.05) better than 1.5mg/kg lidocaine in attenuating pressur response to tracheal intubation.
Conclusion. Intravenous magnesium sulphate is safe and effective at preventing postoperative tachycardia and hypertension and it is better than lidocaine.
Keywords
Magnesium Sulphate, Homodynamic status, Intubation, Operation Complication