HEMODYNAMIC CONTROL AFTER TRACHEAL INTUBATION: LIDOCAINE VS VERAPAMIL

Abstract

Introduction. Laryngoscopy and tracheal intubation cause sympathetic and parasympathetic stimulation that in turn, result in dangerous cardiovascular signs like elevation of systolic and diastolic blood pressure and heart rate. Verapamil and lidocaine have been compared with each other in control of these changes. Methods. In a double blind clinical trial study was done over three groups, each containing so persons, 90th second before intubation, each of which recived verapamil, lidocaine and placebo, respectively. Systolic and diastolic pressure and heart rate were measured and compared together one, two and five minutes after intubation.
Results. Mean of systolic blood pressure was decreased 3.9 and 6.1 percent in verapamil and lidocaine group after laryngoscopy, respectively but it was increased about 2 percent in placebo recipients (P < 0.05). Mean of diastolic blood pressure was decreased in verapamil and lidocaine group 2.1 and 3.9 percent, respectively but increased 2.1 percent in placebo recipient (P < 0.05). Mean of heart rate was decreased 3.1, and 1.8 percent in verapamil and lidocaine group, respectively but increased 5.7 percent in placebo recipient (P < 0.05). Discussion. Lidocaine seems to be more effective than those for prevention of hypertension after laryngoscopy and tracheal intubation. With regard to lower percent of tachycardia in the verapamil groups versus lidocaine and placebo groups, verapamil group is more effective than those about the prevention of tachycardia after laryngoscopy and intubation.