EFFECTS OF REVERSIBLE INACTIVATION OF BILATERAL ACCUMBENS NUCLEI ON MEMORY STORAGE: ANIMAL STUDY IN RAT MODEL
Abstract
Introduction. Memory and learning play an important role in human"s life that will become problematic in case disability is weak for any reason. There are many factors that facilitate process of mamory and learning of which accumbens nucleus plays an important role. Accumbens nucleus, which is a part of the limbic system, is one of many nuclei found of the septum in the mesencephalon. This study was performed to determine the effects of reversible Inactivation of a accumbens nuclei by lidocaein on memory storage in rat.
Method s. Male wistar rats were surgically implancted with cannulae at the accumbens nuclei (Acb) bilaterally one weak later they recived one trial PAL (1 mA 1.S sec) and exactly at times zero, 60 and 120 minutes after posttraining, lidocaine was infused into the Acb. Retention was tested two days after training. Latency period before entering into the dark part of the shuttle box and duration of time in darkness were index for evaluation of retention.
Results. A significant impaired retention performance was at zero and 60 minutes after posttrianing infusion of lidocaine into the Acb. Infusion administered 120 minutes after training had no effect.
Discussion. This study has shown that Accumbens nucleus plays major role in praimary learning and memory and it is probable that by blocking this nucleus dopamine release is diminished which causes the learning process to be delayed consequently.
Method s. Male wistar rats were surgically implancted with cannulae at the accumbens nuclei (Acb) bilaterally one weak later they recived one trial PAL (1 mA 1.S sec) and exactly at times zero, 60 and 120 minutes after posttraining, lidocaine was infused into the Acb. Retention was tested two days after training. Latency period before entering into the dark part of the shuttle box and duration of time in darkness were index for evaluation of retention.
Results. A significant impaired retention performance was at zero and 60 minutes after posttrianing infusion of lidocaine into the Acb. Infusion administered 120 minutes after training had no effect.
Discussion. This study has shown that Accumbens nucleus plays major role in praimary learning and memory and it is probable that by blocking this nucleus dopamine release is diminished which causes the learning process to be delayed consequently.
Keywords
Accumbanse, Passive Avoldame Learning (PAL), Memory, Animal Study