EFFECT OF ORAL CLONIDINE AND INTRAVENOUS LIDOCAINE ON INTRAOCULAR PRESSURE FOLLOWING LARYNGOSCOPY AND INTUBATION

Abstract

Introduction. Control and prevention of increase in ntraocular Pressure (lOP) can affect outcome of ophthalmologic surgical procedures. Sometimes it's necessary to administer a succinylcholine and intubate the trachea in cases of penetrating eye trauma and corneal laceration. The purpose of this study was to investigate the effects of intravenous lidocaine and oral clonidine as premedicants on lOP following administration of succinylcholine and intubation of trachea. Methods. This study was a double blind clinical trial performed on 90 patients aged 20 - 40 years in physical status of ASA I, II (American Society of Anesthesiologists) candidated for nonophthalmic elective surgical procedures. Patients were randomly divided into three groups. The first group received oral clonidine 300 µg/kg, 90-120 minutes before induction(clonidine group). The scond group received IV Lidocaine 1.5mg/kg 3 minutes preceding the induction (lidocaine group) and the third group received no premedicant (control group). Induction and maintenance of anesthesia were performed by identical techniques for all three groups. Results. There was no statistically significant difference of lOP at second and fifth postinduction minutes between clonidine and lidocaine groups(p > 0.05) but this difference was statistically significant between clonidine and control, as well as lidocaine versus control groups (p < 0.05). Discussion. Oral clonidine 300 µg, 90-120 minute preinduction and intravenous lidocaine 1.5mg/kg, 3 minutes preinduction could be used as effective premedicants to prevent increase in lOP following induction with succinylcholine and intubation of trachea.