ANTICARDIOLIPIN ANTIBODY OF ADOLESCENTS AND AGE OF MYOCARDIAL INFARCTION OCCURRENCE IN THEIR PARENTS
Abstract
Introduction: In recent years, different studies have considered a possible association between immunologic factors such as anticardiolipin antibody (Ac/a) and the risk of premature myocardial infarction (MI). In the present study, Acla is compared in patient with premature MI and their children with controls.
Method: In this case-control study, three paired groups (parent-child) of 25 each, were selected by simple random sampling and their Acla levels measured by ELISA method. A comparison was made between parents who had premature MI ( < 55 years of age) and one of their 12-19 year children as the case group, and the parents with MI > 55 years and one of their children, as well as those with no heart attacks and one of their children as the first and second control groups. Data have been analyzed by SPSS/win using the Chi square test.
Result: In this study, the number of positive and or relatively positive titers of Acla was higher in those with premature MI and their children. Also, the percentage of concomitant elevated Acla in parents and their children of the case group was significantly higher than the two control groups (40%vs. 12% and 8% respectively, P < 0.05).
Discussion: The findings of this study point to the probable role of Acla as a risk factor in predicting premature MI. More research is recommended in this regard.
Method: In this case-control study, three paired groups (parent-child) of 25 each, were selected by simple random sampling and their Acla levels measured by ELISA method. A comparison was made between parents who had premature MI ( < 55 years of age) and one of their 12-19 year children as the case group, and the parents with MI > 55 years and one of their children, as well as those with no heart attacks and one of their children as the first and second control groups. Data have been analyzed by SPSS/win using the Chi square test.
Result: In this study, the number of positive and or relatively positive titers of Acla was higher in those with premature MI and their children. Also, the percentage of concomitant elevated Acla in parents and their children of the case group was significantly higher than the two control groups (40%vs. 12% and 8% respectively, P < 0.05).
Discussion: The findings of this study point to the probable role of Acla as a risk factor in predicting premature MI. More research is recommended in this regard.
Keywords
premature myocardial infarction, risk factors, anticardiolipin antibody, children and adolescents