The Relative Frequency, Clinical and Laboratory Findings of Adult Glomerulonephritidies in Tehran
Abstract
Background: Renal diseases information is population-based and has great geographic variability. Due to the lack of national renal data registry system, there is no information on the prevalence rate, and clinical and laboratory features of various glomerulonephritidies (GNs) in Iran.
Methods: In a retrospective cross sectional study, we analyzed 462 adult renal biopsies in Hashemi Nejad hospital, Tehran, Iran. We determined the prevalence rate and the frequency of different clinical and laboratory findings in patients with different GNs. We also compared our results with the reports from other countries.
Results: There were 267(57.8%) males and 195(42.2%) females. The mean age (± SD) was 33.6 ± 15.7 (range, 13-75) years old. After exclusion of 55 biopsies with pathologies other than GNs and in the remaining 407 biopsies, membranous glomerulopathy (MGN) was the most common GN (23.6%), followed by IgAN (13.5%), membranoproliferative GN (11.5%), systemic lupus nephritis (10.6%), focal segmental glomerulosclerosis (10.3%), and minimal change disease (9.8%). These 6 GNs comprised the majority (79.4%) of all GNs.
Conclusion: MGN is the most common form of GN, followed by IgAN, MPGN, SLE-GN, FSGS and MCD in adult patients in our study. The multi-center studies with a larger sample size are needed for more comprehensive data in Iranian population.
Key words: Glomerulonephritidies, Epidemiology, Renal Biopsy, Glomeulopathy
Methods: In a retrospective cross sectional study, we analyzed 462 adult renal biopsies in Hashemi Nejad hospital, Tehran, Iran. We determined the prevalence rate and the frequency of different clinical and laboratory findings in patients with different GNs. We also compared our results with the reports from other countries.
Results: There were 267(57.8%) males and 195(42.2%) females. The mean age (± SD) was 33.6 ± 15.7 (range, 13-75) years old. After exclusion of 55 biopsies with pathologies other than GNs and in the remaining 407 biopsies, membranous glomerulopathy (MGN) was the most common GN (23.6%), followed by IgAN (13.5%), membranoproliferative GN (11.5%), systemic lupus nephritis (10.6%), focal segmental glomerulosclerosis (10.3%), and minimal change disease (9.8%). These 6 GNs comprised the majority (79.4%) of all GNs.
Conclusion: MGN is the most common form of GN, followed by IgAN, MPGN, SLE-GN, FSGS and MCD in adult patients in our study. The multi-center studies with a larger sample size are needed for more comprehensive data in Iranian population.
Key words: Glomerulonephritidies, Epidemiology, Renal Biopsy, Glomeulopathy