An image processing technique for diagnosis of Alzheimer's disease

Massoud Mahmoudian, Soltan Ahmad Ebrahimi, Zahra - Kiani


  • BACKGROUND: Patients with Alzheimer's disease (AD) reportedly hibit hypersensitivity to much diluted tropicam solution (0.005%), a M4 muscarinic receptor antagonist. Therefore aocular application of 0.005% tropicamide ma be useful for screening dementia. The aim of this study was to simplify the pupil response test by using a new image analyzing system, which consists of a cheap, simple, and easy to use web-camera and a computer.
  • METHODS: Intraocular tropicamide of 0.005% concentration was administered in 3 groups: Alzheimer's disease patients (n = 8, average age = 76 ± 5), non-Alzheimer's disease elderly (n = 6, average age = 65 ± 7), and young subjects (n = 8, average age = 28 ± 5). Every 5 minutes for 60 minutes, image of the eye's shape were taken, and the diameter of the pupils was measured.
  • RESULTS: The results showed that differences in pupil dilation rate between Alzheimer's disease and non-Alzheimer's disease subjects were statistically significant. ROC analysis showed that after 35 minutes the sensitivity and specificity of the test were 100%.
  • CONCLUSIONS: Based on our results, we concluded that this recording system might be an appropriate and reliable tool for pupil response diagnosis test of Alzheimer's disease.
  • KEYWORDS: Alzheimer’s Disease, Tropicamide, Pupil.


Alzheimer’s disease, tropicamide, pupil

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