Association of fibrinogen to albumin ratio in patients with isolated coronary artery ectasia

Abstract

Background: Previous research has indicated that chronic inflammation plays a significant role in the development of coronary artery ectasia (CAE). However, there is limited data on the role of plasma fibrinogen?to?albumin ratio (PFAR) in CAE patients. Our study aimed to explore the connection between PFAR and the presence of CAE.

Materials and Methods: This research used a case–control methodology. We included a total of 108 consecutive patients who had CAE without any stenosis. Among them, there were 65 males and 43 females, with a mean age of 58.2 ± 8.5 years. The control group included 102 consecutive participants with angiographically normal coronary arteries, consisting of 62 males and 40 women, with a mean age of 57.3 ± 8.6 years. Statistical analyses were conducted using Student’s?t?test, Mann–Whitney U?test, Chi?square test, linear regression, logistic egression, and receiver operating c aracteristic (ROC) curve analysis.

Results: PFAR in the CAE group was significantly higher compared to the controls (84.8 ± 7.4 vs. 70.1 ± 9.5, P < 0.001). Using multiple logistic regression showed a strong link between PFAR and CAE, with an odds ratio for PFAR of 1.818 (95% confidence interval [CI] 1.092–6.201; P = 0.005). PFAR was exceeded 72.6, the sensitivity and specificity were 80.2% and 72.6%, respectively. The area under the ROC curve (area under the curve) was 0.731 (95% CI: 0.659–0.803, P = 0.028).

Conclusion: In our study, we found that PFAR levels were notably higher in the CAE group compared to the control group, and we observed a significant correlation between PFAR and CAE.