Adiponectin and leptin levels of patients after sleeve gastrectomy, Roux?en?Y gastric bypass, and single anastomosis sleeve ileal bypass surgeries

Seyed Vahid Hosseini, Seyed Ali Hosseini, Hajar Khazraei, Kamran Bagheri Lankarani


Background: Bariatric surgery is an appropriate treatment for obese patients with metabolic syndrome. Adipose tissue is an active endocrine tissue secreting leptin and adiponectin that affect body metabolism. Nowadays, a high incidence of metabolic syndrome with an increased risk of serious diseases has been detected in Shiraz. This study aimed to assess the levels of leptin and adiponectin as well as the  diponectin?to?leptin ratio in three different bariatric surgeries among obese patients in Shiraz. The results will play an important role in physicians’ choice of surgery by distinguishing the effects of these three bariatric surgeries.

Materials and Methods: The serum adiponectin and leptin levels were measured using enzyme?linked immunosorbent assay. Blood glucose, lipid profile, weight, and liver enzyme level were measured before and 7 months after surgery.

Results: This clinical trial was conducted on 81 obese patients who underwent sleeve gastrectomy (SG), Roux?en?Y gastric bypass (RYGB), and single anastomosis sleeve ileal (SASI) bypass surgeries. The results revealed a decrease in fasting blood sugar and triglyceride (TG) levels 7 months after the surgeries. In addition, decrease of body mass index (BMI) was more significantly in the SASI group (12.8 ± 3 4.95) compared to the Roux?en?Y gastric group (8.56 ± 4.61) (P = 0.026). Besides, a more significant improvement in liver function was observed in SG (P < 0.05). Furthermore, the results revealed a significant difference among the three groups regarding the increase in the adiponectin level (P = 0.039). Decrease in the leptin level and increase in the adiponectin level were more significant after the RYGB surgery compared to the SG group (P < 0.05).

Conclusion: The three bariatric surgeries were effective in increasing the
adiponectin level and decreasing the leptin levels. The surgeries also changed the metabolic risk factors including TGs, high?density lipoprotein, fasting blood glucose, and BMI.


Adiponectin, bypass, gastrectomy, leptin, obesity

Full Text: