Isfahan COVID cohort study Rationale, methodology and initial results

Nizal Sarrafzadegan, Noushin Mohammadifard, Shaghayegh Haghjooy Javanmard, Fahimeh Haghighatdoost, Fatemeh Nouri, Mahshid Ahmadian, Maryam Nasirian, Maedeh Sayyah, Jamshid Najafian, Mohammadreza Shafiei, Hassan Alikhasi, Sahel Javanbakht, Farzaneh Nilforoushzadeh, Fahimeh Bagheri, Shahla Shahidi, Mostafa Rezaei, Kamal Heidari, Behrouz Keleidari, Tahereh Changiz


Background: The Isfahan COVID Cohort (ICC) study was designed to investigate the short? and long?term consequences of patients with COVID?19 in Iran. This report presents the rationale, methodology, and initial results of ICC. Materials and Methods: ICC is a 5?year multicentric prospective cohort study that is ongoing on two groups including 5000 patients hospitalized with moderate or severe and 800 nonhospitalized patients with mild or asymptomatic COVID?19 in Isfahan. The ICC  ndpoints are morbidity, mortality, incident cases, or worsening of  nderlying noncommunicable diseases (NCDs) and their risk factors. In the current analysis, we examined the persistent symptoms and incident  CDs or risk factors in 819 previously hospitalized patients who completed 1?year follow?up. Results: The two most common symptoms were joint pain/myalgia (19.7%) and dry cough/dyspnea (18.7%). Around 60% of patients had at least one symptom which was more common among  omen than men and in middle aged than younger or older patients.  emale (odds ratio [OR] =1.88, 95% confidence interval [CI]: 1.39–2.55) and highly?educated patients (OR = 2.18, 95% CI: 1.56–3.04) had higher risk of having any symptom in 1?year follow?up. New cases of hypertension followed by diabetes then coronary heart disease (CHD) were the most common incident NCDs. Conclusion: During 1?year follow?up after hospital discharge, about 60% of patients experienced persistent symptoms. Incident hypertension, diabetes, and CHD were the most common events seen. Close monitoring and extensive health  ervices with integrative approaches are needed to improve the health status of these patients.


COVID?19, morbidity, mortality, outcome, prospective cohort study, symptom

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