Association between serum Vitamin D levels and prognostic factors in nonmetastatic breast cancer patients

Mohammad Karim Shahrzad, Reyhaneh Gharehgozlou, Sara Fadaei, Parastoo Hajian, Hamid Reza Mirzaei


Background: Breast cancer is among the most common malignancies in women around the world. There is evidence of high prevalence of serum/blood Vitamin D deficiency in Iranian women. Considering the multitude of factors that may be involved in the prognosis and lifespan of breast cancer patients, this study investigated the level of Vitamin D in  ranian patients with nonmetastatic breast cancer. Materials and Methods:  his cross?sectional study was carried out on 214 women diagnosed with breast cancer, who were referred to the radio?oncology department.  erum Vitamin D level of the patients was measured. Prognostic factors  ere determined based on demographic and pathological characteristics.  he results were analyzed using descriptive statistics tests, Chi?square,  ne?way analysis of variance, Kaplan–Meier, and Cox regression model in SPSS v22. For all cases, the significance level was considered to be P < 0.05. Results: The total mean of 25?hydroxyvitamin D serum level was  5.15 ± 17.68 ng/ml. There was no significant relationship between levels of Vitamin D with disease stage, tumor size, tumor grade, estrogen  eceptor, progesterone receptor, and Human epidermal growth factor  eceptor 2 (P > 0.05). The mean survival time was 5 years and 45 days. Conclusion: No relationship was found between serum Vitamin D levels and the factors affecting the prognosis of nonmetastatic breast cancer. The Cox analysis showed that the survival time was not influenced by  itamin D as a prognosis factor.


Breast cancer, prognosis, Vitamin D Address for

Full Text: