Transforming growth factor B3 relation with osteoporosis and osteoporotic fractures

Abstract

Background: Te high socioeconomic impact of osteoporosis and osteoporotic fracture is due to their high mortality, morbidity, and disease-related costs. Nowadays, bone mineral density (BMD) is a comparatively expensive way to diagnose and follow up patients with osteoporosis. Transforming growth factor-B3 (TGF-B3) is a protein categorized into cytokines. Some previous in vitro studies showed TGF-B3 effects on osteocytes and bone formation. Terefore, we conducted this study to fnd if there is any signifcant relationship between TGF-B3 and BMD results. Materials and Methods: Tis was an analytical cross-sectional study conducted in 2017. We included individuals who had been referred from their physicians to undergo BMD dual-energy X-ray absorptiometry. Blood samples were taken from 150 participants for measuring TGF-B3 with ELISA method. Results: The mean ± standard deviation of TGF-B3 serum level was 79 ± 30.8 pg/ml (minimum 41 pg/ml and maximum 210 pg/ml). Tere was a statistically signifcant and direct proportional relationship between TGF-B3 and T-score as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture (P = 0.001) (Pearson’s correlation = +0.95). Conclusion: Tere was a signifcant relationship between TGF-B3 serum level and BMD. TGF-B3 serum level may be used as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture.