Post-traumatic endophthalmitis prophylaxis with oral ciprofloxacin in comparison to intravenous cephazolin/gentamicin

Alireza Dehghani, Amir Masood Rafemanzelat, Kimia Ghaderi, Mohsen Pourazizi, Awat Feizi


Introduction: Although posttraumatic endophthalmitis is an uncommon condition, it causes severe complications, so medical and pharmacological interventions for prevention of endophthalmitis after trauma are a major concern. Te aim of this study was to evaluate the efcacy and clinical outcome of oral cipro?oxacin versus intravenous cefazolin/gentamicin for the prevention of endophthalmitis after penetrating ocular trauma. Materials and Methods: Tis was a retrospective, descriptive single?center study, including all cases of penetrating ocular trauma seen in the Feiz Hospital, a Tertiary Referral Eye Hospital in Isfahan, Iran, between 2011 and 2017. Data systemically recorded for each patient included clinical, ophthalmological, and demographic fndings by a trained medical record abstractor or ophthalmologist reviewing patient records. Results: Six hundred and forty?fve patients in cefazolin/gentamicin and 273 patients in oral cipro?oxacin groups were included in the study. Our study showed that the incidence of endophthalmitis was not signifcantly di?erent between the two groups (P = 0.463). In patients with either sharp or blunt penetrating ocular trauma. Conclusion: Oral cipro?oxacin as a prophylactic treatment could prevent posttraumatic endophthalmitis as e?ective as injectable cefazolin/gentamicin. Due to easier consumption of oral cipro?oxacin and lower systemic complications, in all patients with penetrating eye trauma, oral administration of cipro?oxacin is preferable to intravenous or intramuscular types of antibiotics to reduce the risk of posttraumatic endophthalmitis.


Cefazolin, cipro?oxacin, endophthalmitis, gentamicin, penetrating ocular trauma

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