Is neutrophil gelatinase?associated lipocalin a good diagnostic marker for renal injury in asphyxiated preterm infants?
However, blood gas, Apgar score, and resuscitation showed a signifcant di?erence (P < 0.05). (2) In 24?h samples, only uNGAL and estimated glomerular fltration rate (eGFR) showed di?erences between the two groups (P < 0.05). In 48?h samples, signifcant di?erences could be found in uKIM?1, uNGAL, blood urea nitrogen, and eGFR (P < 0.05). In 96?h samples, almost all indicators have signifcant di?erences except urine output and eGFR (P < 0.05). (3) All biomarkers showed statistical di?erence in the three time points (P < 0.05), but only uNGAL showed a downward trend after the increase of expression. (4) uNGAL has better Sen and Spe than other indicators (24?h AUC 0.870, Youden index 0.606; 48?h AUC 0.879, Youden index 0.692; and 96?h AUC 0.806, Youden index 0.606). Conclusion: uNGAL has a better distinguishability in asphyxial neonates compared with other indicators. Certainly, a larger sample, prospective study is still needed.
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