Attenuation of lipid peroxidation and atherogenic factors in diabetic patients treated with gliclazide and metformin
Abstract
Background: Diabetes is associated with oxidative stress and considered as a major risk factor for cardiac disease. We attempted to investigate the role of oral antidiabetic (OAD) agents gliclazide and metformin in lowering the lipid peroxidation and managing the risk for cardiovascular (CV) complications in diabetic patients in comparison with nondiabetic healthy
individuals. Materials and Methods: Tis cross?sectional study was comprised of 150 individuals grouped in three, namely, Group A (n = 60) healthy volunteers, Group B (n = 30) newly diagnosed diabetes, and Group C (n = 60) diabetes treated with OAD. Serum malondialdehyde (MDA), nitric oxide (NO), and Vitamin C were assessed for studying lipid peroxidation status, whereas serum triglyceride (TG) and total cholesterol were monitored as predictors for CV risk. Results: We found signifcantly higher concentrations of MDA and NO levels (P < 0.001) in both groups of patients (Group B and C) in comparison to control group (Group A). Regarding antioxidants, signifcantly lower concentrations of Vitamin C (P = 0.046) were found in Group B and C compared to Group A. Moreover, there was signifcant di?erence exhibited in concentration level of MDA (P = 0.001) and NO (P = 0.015) between Group B and C, whereas di?erence of Vitamin C (P = 0.147) was not statistically signifcant. Conclusions: Our data confrmed that
treatment with gliclazide and metformin signifcantly reduced the lipid peroxidation accompanied with attenuated levels of serum TGs and cholesterol and suggested that oral hypoglycemic agents have great impact to reduce the oxidative stress and increase the
antioxidant status in diabetes.
individuals. Materials and Methods: Tis cross?sectional study was comprised of 150 individuals grouped in three, namely, Group A (n = 60) healthy volunteers, Group B (n = 30) newly diagnosed diabetes, and Group C (n = 60) diabetes treated with OAD. Serum malondialdehyde (MDA), nitric oxide (NO), and Vitamin C were assessed for studying lipid peroxidation status, whereas serum triglyceride (TG) and total cholesterol were monitored as predictors for CV risk. Results: We found signifcantly higher concentrations of MDA and NO levels (P < 0.001) in both groups of patients (Group B and C) in comparison to control group (Group A). Regarding antioxidants, signifcantly lower concentrations of Vitamin C (P = 0.046) were found in Group B and C compared to Group A. Moreover, there was signifcant di?erence exhibited in concentration level of MDA (P = 0.001) and NO (P = 0.015) between Group B and C, whereas di?erence of Vitamin C (P = 0.147) was not statistically signifcant. Conclusions: Our data confrmed that
treatment with gliclazide and metformin signifcantly reduced the lipid peroxidation accompanied with attenuated levels of serum TGs and cholesterol and suggested that oral hypoglycemic agents have great impact to reduce the oxidative stress and increase the
antioxidant status in diabetes.
Keywords
Antioxidant, atherogenic factors, cholesterol, lipid peroxidation, oral antidiabetic drugs, type 2 diabetes