Journal of Research in Medical Sciences 2018. 23(7):J Res Med Sci 2018, 23:59 (26 July 2018).

Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus
Supakanya Lasom, Nantarat Komanasin, Nongnuch Settasatian, Chatri Settasatian, Upa Kukongviriyapan, Pongsak Intharapetch

Abstract


Background: Te imbalance of von Willebrand factor (vWF) and a disintegrin and metalloproteinase with a thrombospondin type 1
motif member 13 (ADAMTS13) has been associated with atherosclerosis progression. A high level of vWF which regulates thrombus formation is associated with diabetes mellitus (DM), and some ADAMTS13 and vWF polymorphisms have e?ects on their levels. Terefore, this study aimed to evaluate the associations of ADAMTS13 and vWF polymorphisms and their levels with DM and severity of coronary stenosis. Materials and Methods: Eighty?seven DM and 84 control individuals were recruited. vWF and ADAMTS13 activities as well as vWF antigen were measured by collagen?binding assay (CBA), residual?CBA, and in?house enzyme?linked
immunosorbent assay, respectively. ADAMTS13 and vWF polymorphisms were determined by polymerase chain reaction?restriction fragment length polymorphism. Results: Te E and G alleles and AA genotype of ADAMTS13 Q448E, rs2073932, and rs652600, respectively, were independently associated with DM (odds ratio [OR] [95% confdence interval (CI)] = 2.5 [1.1, 5.6], 2.3 [1.0, 5.2], and 4.7 [1.2, 18.6], respectively). Moreover, E allele and AA genotype of Q448E and rs652600 were also signifcantly associated with multi?vessel disease (OR [95% CI] = 2.2 [1.0, 4.8] and 3.2 [1.0, 10.0], respectively), while the E and G allele of Q448E and rs2073932 were associated with high Gensini score (OR [95% CI] = 2.3 [1.1, 4.9] and 2.3 [1.1, 5.1], respectively). Conclusion: Association of
ADAMTS13 polymorphisms with DM, number of vessel stenosis, and Gensini score may indicate the possible contribution of ADAMTS13 polymorphisms to atherosclerosis progression and severity of coronary stenosis in DM.


Keywords


A disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13, coronary stenosis, diabetes mellitus, polymorphism

Full Text: PDF
This article has been downloaded 61 times up to now.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.