Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus
group (n = 113), active SLE group (n = 54), and inactive SLE group (n = 37). Demographic, clinical, and laboratory data were analyzed.
Results: In patient group, PDW was statistically higher than that in control group (13.54 ± 2.67 vs. 12.65 ± 2.34, P = 0.012), and in active group, PDW was signifcantly increased compared to inactive group (14.31 ± 2.90 vs. 12.25 ± 1.55, P < 0.001). However, MPV was signifcantly lower in SLE group than in control group (10.74 ± 0.94 vs. 11.09 ± 1.14, P = 0.016). PDW was positively correlated with SLE disease activity index (P < 0.001, r = 0.529) and erythrocyte sedimentation rate (P = 0.002, r = 0.321) and negatively correlated with C3 (P < 0.001, r = -0.419). However, there was no signifcant association between MPV and these study variables. A PDW level of 11.85% was determined as a predictive cuto? value of SLE diagnosis (sensitivity 76.9%, specifcity 42.5%) and 13.65% as cuto? of
active stage (sensitivity 52.6%, specifcity 85.3%). Conclusions: Tis study frst associates a higher PDW level with an increased SLE activity, suggesting PDW as a novel indicator to monitor the activity of SLE.
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