Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus
Abstract
Background: Signifcance of platelet distribution width (PDW) and mean platelet volume (MPV) in assessing disease activity of systemic lupus erythematosus (SLE) remains unclear. Tis study was aimed to evaluate PDW and MPV as potential disease activity markers in adult SLE patients. Materials and Methods: A total of 204 study participants, including 91 SLE patients and 113 age? and gender?matched healthy controls, were selected in this cross?sectional study. Tey were classifed into three groups: control
group (n = 113), active SLE group (n = 54), and inactive SLE group (n = 37). Demographic, clinical, and laboratory data were analyzed.
Results: In patient group, PDW was statistically higher than that in control group (13.54 ± 2.67 vs. 12.65 ± 2.34, P = 0.012), and in active group, PDW was signifcantly increased compared to inactive group (14.31 ± 2.90 vs. 12.25 ± 1.55, P < 0.001). However, MPV was signifcantly lower in SLE group than in control group (10.74 ± 0.94 vs. 11.09 ± 1.14, P = 0.016). PDW was positively correlated with SLE disease activity index (P < 0.001, r = 0.529) and erythrocyte sedimentation rate (P = 0.002, r = 0.321) and negatively correlated with C3 (P < 0.001, r = -0.419). However, there was no signifcant association between MPV and these study variables. A PDW level of 11.85% was determined as a predictive cuto? value of SLE diagnosis (sensitivity 76.9%, specifcity 42.5%) and 13.65% as cuto? of
active stage (sensitivity 52.6%, specifcity 85.3%). Conclusions: Tis study frst associates a higher PDW level with an increased SLE activity, suggesting PDW as a novel indicator to monitor the activity of SLE.
group (n = 113), active SLE group (n = 54), and inactive SLE group (n = 37). Demographic, clinical, and laboratory data were analyzed.
Results: In patient group, PDW was statistically higher than that in control group (13.54 ± 2.67 vs. 12.65 ± 2.34, P = 0.012), and in active group, PDW was signifcantly increased compared to inactive group (14.31 ± 2.90 vs. 12.25 ± 1.55, P < 0.001). However, MPV was signifcantly lower in SLE group than in control group (10.74 ± 0.94 vs. 11.09 ± 1.14, P = 0.016). PDW was positively correlated with SLE disease activity index (P < 0.001, r = 0.529) and erythrocyte sedimentation rate (P = 0.002, r = 0.321) and negatively correlated with C3 (P < 0.001, r = -0.419). However, there was no signifcant association between MPV and these study variables. A PDW level of 11.85% was determined as a predictive cuto? value of SLE diagnosis (sensitivity 76.9%, specifcity 42.5%) and 13.65% as cuto? of
active stage (sensitivity 52.6%, specifcity 85.3%). Conclusions: Tis study frst associates a higher PDW level with an increased SLE activity, suggesting PDW as a novel indicator to monitor the activity of SLE.
Keywords
Biomarkers, blood platelets, systemic lupus erythematosus