Journal of Research in Medical Sciences 2018. 23(4):J Res Med Sci 2018, 23:31 (26 April 2018).

Comparison of salivary testosterone levels in different phases of bipolar I disorder and control group
Sabra Mousavizadegan, Mohsen Maroufi


Background: Testosterone is considered as a primary sex hormone, also known as an important anabolic steroid, that may involve in various mental disorders such as bipolar I disorder (BID). Te goal of this study was to compare the testosterone salivary levels between di?erent phases of BID and its association with the clinical features of BID. Materials and Methods: In a case–control study, 15 patients in the mania phase, 10 patients in the depression phase, and 16 in the euthymia phase were selected as patient
groups. 18 healthy sex? and age?matched individuals were considered as healthy control group. Salivary samples obtained from all patients and control group and levels of testosterone were determined in saliva using an enzyme?linked immunosorbent assay. All statistical calculations were conducted with the software Statistical Package for Social Science version 20 (IBM Inc., Chicago, IL, USA). Results: Te mean testosterone level in euthymia phase was 186.34 ± 182.62 pg/mL, mania phase was 239.29 ± 273.22 pg/mL,     depression was 153.49 ± 222.50 pg/mL, and healthy participants was 155.73 ± 126.0 pg/mL; no signifcant di?erence was found
between groups (P = 0.68.( No statistically signifcant di?erences were found between psychotic and nonpsychotic as well as between patients who  attempted suicide and nonattempter patients in terms of testosterone levels (P > 0.1). Conclusion: Our fndings do not reveal signifcant di?erence between di?erent phases of BID in terms of salivary testosterone levels. However, more comprehensive studies with larger sample size are required to confrm our fndings.


Bipolar disorder, depression, euthymia, mania, testosterone

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