The prognostic value of lymph node ratio in survival of head?and?neck squamous cell carcinoma
We noticed an association between LNR and survival by Kaplan–Meier analysis. Hazard ratio (HR) of LNR was determined by Cox’s regression model. Results: Two hundred and one patients entered this study after their medical histories were evaluated. Te mean of lymph node count and LNR was 14.30 (±9.50) and 0.12 (±0.23), respectively. Eighty patients (39.80%) experienced recurrence of SCC. Five?year OS, DFS, and LFFS were 32%, 21%, and 64%, respectively. Te median of OS was 40.70 months and 30.11 months in patients with LNR of ?0.06 and >0.06, respectively (P < 0.01). Te LNR >0.06 was found to be a signifcant prognostic factor for lower OS of patients with HNSCC (HR = 2.11 [1.10, 4.40]; P = 0.04). DFS was not signifcantly di?erent among patients with LNR ?0.06 and patients with LNR >0.06 (P = 0.9). However, LFFS was slightly di?erent among two groups (HR = 2.04 [0.90–4.80]; P < 0.1). Conclusion: We recommend more intensive adjuvant therapies such as chemotherapy with radiotherapy and short interval follow?up for patients with LNR >0.06. Further investigations with larger sample sizes are recommended.
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