Correlation between Vitamin D3 level and extrahepatic manifestation in chronic hepatitis type?C virus patients
Abstract
Background: Chronic hepatitis type?C virus (HCV) infection is one of the most common worldwide viral disorders, which leads to various clinical complications as well as extrahepatic manifestations. Furthermore, Vitamin D3 has also been reported to have relationship with the mentioned complications. Te aim is to evaluate the correlation between Vitamin D3 level and extrahepatic manifestation in chronic HCV patients. Materials and Methods: Tis cross?sectional study has been carried out on 90 patients
with chronic hepatitis C. Te level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic anifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed. Results: Most of our patients were male (92% vs. 8%). Twenty?nine percent had the insufcient amount of Vitamin D3 (21–30 ng/ml), and the remains had the
Vitamin D3 level between 13–20 ng/ml. Furthermore, our assessment demonstrated that defciency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confdence interval (CI) 95%] = 8.80 [1.74–44.47], P = 0.004), vasculitis (OR [95% CI] = 11.70 [3.01–45.41], P < 0.001), arthralgia (OR [95% CI] = 20.26 [4.21–97.47], P < 0.001), myalgia (OR [95% CI] = 4.00 [1.01–17.27], P = 0.048), and glomerulonephritis (P = 0.021). Conclusions: According to our results, the extrahepatic manifestation in the patients with sufcient levels of Vitamin D3 would be less possible. In fact, it could be stated that defciency in the Vitamin D3 can have a signifcant relationship with these manifestations.
with chronic hepatitis C. Te level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic anifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed. Results: Most of our patients were male (92% vs. 8%). Twenty?nine percent had the insufcient amount of Vitamin D3 (21–30 ng/ml), and the remains had the
Vitamin D3 level between 13–20 ng/ml. Furthermore, our assessment demonstrated that defciency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confdence interval (CI) 95%] = 8.80 [1.74–44.47], P = 0.004), vasculitis (OR [95% CI] = 11.70 [3.01–45.41], P < 0.001), arthralgia (OR [95% CI] = 20.26 [4.21–97.47], P < 0.001), myalgia (OR [95% CI] = 4.00 [1.01–17.27], P = 0.048), and glomerulonephritis (P = 0.021). Conclusions: According to our results, the extrahepatic manifestation in the patients with sufcient levels of Vitamin D3 would be less possible. In fact, it could be stated that defciency in the Vitamin D3 can have a signifcant relationship with these manifestations.
Keywords
25?hydroxy Vitamin D3, extrahepatic manifestations, hepatitis type?C virus