Therapeutic impacts of microRNAs in breast cancer by their roles in regulating processes involved in this disease

Amir Mehrgou, Mansoureh Akouchekian


Breast cancer is the most common cancer in women around the world. So far, many attempts have been made to treat this disease, but few e?ective treatments have been discovered. In this work, we reviewed the related  articles in the limited period of time, 2000–2016, through search in  PubMed, Scopus database, Google Scholar, and psychology and psychiatry literature (PsycINFO). We selected the articles about the correlation of microRNAs (miRNAs) and breast cancer in the insight into therapeutic  applicability from mentioned genetics research databases. Te miRNAs as an e?ective therapy for breast cancer was at the center of our attention. Hormone therapy and chemotherapy are two major methods that are being used frequently in breast cancer treatment. In the search for an e?ective therapy for breast cancer, miRNAs suggest a promising method of  treatment. miRNAs are small, noncoding RNAs that can turn genes on or o? and can have critical roles in cancer treatment; therefore, in the near  future, usage of these biological molecules in breast cancer treatment can be considered a weapon against most common cancer?related concerns in women. Here, we discuss miRNAs and their roles in various aspects of  breast cancer treatment to help fnd an alternative and e?ective way to treat
or even cure this preventable disease.


Breast cancer, chemotherapy, hormone therapy, microRNA, treatment

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