Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus

Aleksandra Klisic, Nebojsa Kavaric, Milovan Jovanovic, Elvir Zvrko, Verica Skerovic, Andjelka Scepanovic, Darko Medin, Ana Ninic


Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Terefore, we aimed to evaluate the in?uence of lipidparameters on long?term glycemic control in DM2. Materials and Methods: A total of 275 sedentary DM2 (mean [±standarddeviation] age 60.6 [±10.0] years) who volunteered toparticipate in this cross?sectional study were enrolled. Anthropometric (bodyweight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), aswell as blood pressure were obtained. Results: Total cholesterol (odds ratio [OR] =1.30, 95% confdence interval [CI] [1.02–1.66],P = 0.032), triglycerides (OR = 1.34, 95% CI (1.07–1.67), P = 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95%CI [1.10–1.83], P = 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilitiesof higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high?density lipoprotein cholesterol (HDL?c) was foundto be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20–0.67], P = 0.039), and increase in HDL?c by 1 mmol/L,reduced the probability of higher HBA1c by 56%. Conclusion: Unfavorable lipid profle can predict HbA1c level in DM2 patients.Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measurefor optimal long?term glycemic control.


Diabetes mellitus, dyslipidemia, glycated hemoglobin, glycemic control

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