Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature

Abstract

Hydatid cyst is the larval stage of dog tape worm Echinococcus granulosus. Protoscolices are parasite larvae that develop into adult worms in the fnal host intestine. During surgical treatment of human hydatidsosis spillage of live protoscolices is the major cause of hydatidosis recurrence. To prevent this problem scolicidal agent such as hypertonic salt are used to kill the protoscolices that may disseminate into the patient’s tissues during surgery. However, they may have some unacceptable side e?ects. To fnd scolicidal agents with high efcacy, the e?ect of di?erent compounds on  protoscolices of hydatid cyst in vitro has been reviewed. Using PubMed,
Scopus, Google Scholar, and SID databases articles about scolicidal e?ects of di?erent agents on protoscolices of hydatid cyst in vitro were collected. Foeniculum vulgare after 5 min, metalonic extracts of Allium sativum and hypertonic saline after 10 min, and warm water after 2 min kill all alive protoscolices. Te above agents that in minimum time and minimum concentration have 100% scolicidal activity, could be good candidates for further investigations.