The relationship between Vitamin D, clinical outcomes, and mortality rate in Intensive Care Unit patients: A prospective observational study

Abstract

Background: According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25?hydroxyvitamin D (25(OH)D) and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association. Materials and Methods: Serum 25(OH)D, C?reactive protein, malnutrition measurements, and Intensive Care Unit (ICU)?acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes. Results: About  93.5% of patients were classified as deficient and insufficient while the others were categorized in sufficient group. 25(OH)D status was not significantly associated with mortality rate (P = 0.66), and no significant differences in ventilation time were observed (P = 0.97). Sufficient group left the ICU sooner, but the difference was not significant (P = 0.75). Besides the results of relationship between 25(OH)D concentration and nutritional status (P = 0.69) were not significant. In addition, sufficient group suffered from infection more than insufficient patients, but this relationship was not significant (P = 0.11). Conclusion: In this study, we found that 25(OH)D insufficiency is common in ICU patients, but no significant association between low  25(OH)D levels and ICU outcomes were observed. Hence, because of vital roles of Vitamin D in human’s body, comprehensive study should conduct to determine the decisive results.

Key words: 25?hydroxyvitamin D, hospital?acquired infection, inflammation, Intensive Care Unit, length of stay, malnutrition,
mortality, ventilation time