Marine-Lenhart syndrome with papillary thyroid carcinoma

Hulusi Atmaca, Ramis Çolak, Zihni Acar Yazici, Mehmet Kefeli, Fevziye Canbaz Tosun


Graves’ disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves’ thyroid tissue are almost always benign  in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves’ disease and AFTN. Total thyroidectomy was performed. The hyperfunctioning nodule with centrally hypoactive foci detected by technetium-99m thyroid scanning was histologically diagnosed as papillary thyroid carcinoma that was 2.5 cm in diameter. We report the presence of papillary thyroid carcinoma within AFTN in patients with Marine-Lenhart syndrome, which has not been reported so far.

Key words: Autonomously functioning thyroid nodule, Graves’ disease, hyperthyroidism, Marine-Lenhart syndrome, papillary microcarcinoma, papillary thyroid carcinoma, thyroid scintigraphy, toxic nodular goitre

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