Interstitial pregnancy treated with a single-dose of systemic methotrexate: A successful management

Serena Corioni, Federica Perelli, Claudia Bianchi, Mauro Cozzolino, Luana Maggio, Giulia Masini, Maria Elisabetta Coccia


Interstitial pregnancy is an ectopic pregnancy at high hemorrhagic risk. It often poses a diagnostic and therapeutic challenge to the clinician, with a significant risk of morbidity and mortality. It presents a difficult management problem with no absolute standard of care; the most appropriate treatment technique for these pregnancies remains controversial. We describe a case of unruptured interstitial pregnancy successfully treated with a single-dose of systemic methotrexate with subsequent ultrasound and serum beta human chorionic gonadotropin monitoring. Medical management can be a safe and successful option in selected cases that satisfy specific criteria and in women who are able to be monitored after treatment.


Key words: Ectopic pregnancy, human chorionic gonadotropin monitoring, interstitial pregnancy, medical management, medical treatment, methotrexate, noninvasive treatment, ultrasound monitoring

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