Vasculitis and long standing ankylosing spondylitis in a patient with familial Mediterranean fever

Ali Taylan, Yasar Yildiz, Ismail Sari, Guliz Ozkok

Abstract


Coexistence of familial Mediterranean fever (FMF) and other

infl ammatory disorders has been frequently reported, but no specific underlying factor has been identified. We report a patient with FMF who is presented with long-standing ankylosing spondylitis
(AS) and cutaneous leukocytoklastic vasculitis (LV) of the lower limbs. It is the first report on combination of FMF with AS and LV.
The Mediterranean Fever (MEFV) gene mutation of heterozygote (R202Q/R726A) and HLA-B27 are detected in this case, and are
believed to form genetic susceptibility to LV.
Key words: Ankylosing spondylitis, familial Mediterranean fever, leukocytoklastic vasculitis, vasculitis


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