Journal of Research in Medical Sciences1735-19952834202309041146311463EN20230904<p>Background: Whether combination administration of angiotensin?converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and beta?blockers (BBs) has a “reversal” effect on cardiac structure and function for first?diagnosed idiopathic dilated cardiomyopathy (FSIDCM) patients with unclear etiologies and inducements is unknown.</p><p>Materials and Methods: We studied the effect of the protocol on FSIDCM patients. The effect was investigated in 26 FSIDCM patients. The criteria of “complete reversal” included left ventricular end?diastolic diameter (LVEDD) ?50 mm for females or ?55 mm for males and left ventricular ejection fraction (LVEF) ?45%; the criteria of “partial reversal” was the decreased rate of LVEDD (?LVEDD) &gt;10% or the increase rate of LVEF (?LVEF) &gt;10%; the criteria of “no reversal” included LVEDD &gt;50 mm for females or &gt;55 mm for males and ?LVEDD &lt;10%, and LVEF &lt;45% and ?LVEF &lt;10%.</p><p>Results: Within the follow?up period, nine patients showed “complete reversal,” eight “partial reversal,” and nine “no reversal.” Improvements in echocardiogram parameters were the most significant in “complete reversal” patients (P &lt; 0.001), followed by “partial reversal” and “no reversal” patients (P &lt; 0.05). The QRS (Q wave, R wave, S wave) duration and symptoms duration in “complete reversal” patients were the shortest, followed by “partial reversal” and “no reversal” patients.</p><p>Conclusion: ACEIs or ARBs and BBs have a “complete reversal” effect on the left ventricular size and function of some FSIDCM patients. Patients with a narrow QRS and short symptom duration may have a good response.</p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11463http://jrms.mui.ac.ir/index.php/jrms/article/download/11463/6273

Journal of Research in Medical Sciences1735-19952834202309041146511465EN20230904<p><strong>Background:</strong> Osteoporosis, a prevalent bone malady, is prevalent in Iran. Several studies have represented the role of dietary antioxidants on osteoporosis. The dietary antioxidant index (DAI) is a valid and reliable index, which indicates a comprehensive view of dietary antioxidant capacity. This study aimed to survey the relationship of the DAI with the risk of osteoporosis in postmenopausal women in Iran. This research aimed to examine the association between the DAI and the risk of osteoporosis among postmenopausal women in Iran.</p><p><strong> Materials and Methods:</strong> In this case–control study, 440 postmenopausal women (220 cases and 220 controls) were enrolled. The dietary intake of contributors was evaluated using a 147?item food frequency questionnaire. To estimate the DAI, the amount of six antioxidant micronutrients such as Vitamins A, C, and E, selenium, manganese, and zinc was standardized. Then, the DAI was estimated by collecting the standardized  onsumption of these antioxidant micronutrients.</p><p><strong>Results:</strong> Our findings represented<br />the participants in the first (crude odds ratio [OR] = 1.79, 95% confidence interval [CI]: 1.13–2.85, P = 0.013) and second (crude OR = 1.60, 95% CI: 1.01–2.55, P = 0.043) tertiles of the DAI scores had significantly higher odds of osteoporosis compared to those in the third one; while after modifying for confounding factors, this significant reverse relationship was observed just between women in the first and third tertiles of the DAI scores (adjusted OR = 1.90, 95% CI: 1.34–3.18, P = 0.015).</p><p><strong> Conclusion:</strong> The consequence of this study suggested that adherence to a diet rich in antioxidant compounds may have protective effects against osteoporosis.<br /><br /></p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11465http://jrms.mui.ac.ir/index.php/jrms/article/download/11465/6276

Journal of Research in Medical Sciences1735-19952834202309041146611466EN20230904<p><strong>Background:</strong> Breast cancer is the second type of cancer in the world. Some internal and external risk factors, especially infection diseases, can progress breast cancer. As the relation between varicella zoster virus (VZV), human papillomavirus (HPV), herpes simplex virus type 2 (HSV?2), and breast cancer has not been understood, it was attempting to find the effect of these viruses and breast cancer in this study.</p><p><strong>Materials and Methods:</strong> We collected 40 breast cancer and 50 healthy adjacent tissues from Taleghani and Imam Hossein Hospital, Tehran, Iran, in 3 years starting in 2017. After extracting DNA from breast tissues, multiplex polymerase chain reaction (PCR), nested PCR, and PCR were done to analyze the prevalence of HSV?2, VZV, and HPV.</p><p><strong>Results:</strong> Our results showed that HPV may be one of the important causes of breast cancer. Nested PCR illustrated nine breast cancerous tissues (mean age: 43) and three healthy adjacent ones (mean age: 41) were infected by HPV. Phylogenetic analysis illustrated that all of the infected HPV cancerous and healthy tissues were HPV 18 (except two healthy samples infected with HPV 6).  mevertheless, there were not any infected tissues by HSV?2 and VZV.</p><p><strong>Conclusion:</strong> It seems that HPV virus type 18 can have high prevalence in breast cancerous tissues in comparison with healthy adjacent ones, and it is likely to have an effect on breast cancer progression. However, the opposite trend is true for HSV?2 and VZV as we did not find any differences between different kinds of breast tissues.</p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11466http://jrms.mui.ac.ir/index.php/jrms/article/download/11466/6277

Journal of Research in Medical Sciences1735-19952834202309041146811468EN20230904<p><strong>Background:</strong> Povidone Iodine (PI) is the most frequent antiseptic used as a topical disinfectant in surgery. It has been reported high transcutaneous iodine absorption due to topical PI usage, but there is a lack of data in periods of excess iodine depletion.<br /><strong>Materials and Methods:</strong> This is a cross-sectional study designed to assess serial urinary iodine concentration (UIC) after topical administration of PI to evaluate the transcutaneous iodine absorption and the proper iodine depletion time for safe administration of Radio Active Iodine (RAI) therapy as ablative or adjuvant therapy. <strong></strong></p><p><strong>Results:</strong> Thirty-seven patients with papillary thyroid carcinoma undergoing total thyroidectomy were assigned to the PI group (n = 20) or chlorhexidine gluconate (CHG) group (n = 17). In the PI group, the UIC levels rose to a maximum of 2 times in the 4th week after administration and returned to pre-operative levels in the 8th week after. In the CHG group, there was a decrease in UIC levels due to a low iodine diet (LID) with a significant P-value of 0.001, &lt;0.001, and 0.001 in the 2nd, 4th, and 8th weeks follow up respectively compared to the PI group. The urinary excretion of excess iodine lasts about 8 weeks after total thyroidectomy until iodine levels turn back to pre-operative values.</p><p><strong> Conclusion:</strong> If the thyroidectomy was prepared with PI, RAI is better to be performed 6-8 weeks after surgery rather than the standard prescription of 4 weeks.<br /><br /></p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11468http://jrms.mui.ac.ir/index.php/jrms/article/download/11468/6278

Journal of Research in Medical Sciences1735-19952834202309041146411464EN20230904<p>Background: Different virulence factors are involved in the pathogenesis of urinary tract infection (UTI) caused by Uropathogenic Escherichia coli (UPEC); hence, this study aimed to study the prevalence of biofilm formation, virulence factors, and phylogenetic groups and their correlation with biofilm formation among UPEC isolates through a systematic review and meta?analysis.</p><p>Materials and Methods: A literature search was conducted from 1, 2000, to the end of 2021 in different databases for studies that reported biofilm together with virulence genes or phylogenetic groups in UPEC isolates from patients with UTI according to PRISMA protocol. Data were analyzed by Comprehensive meta?analysis software.</p><p>Results: The pooled prevalence of biofilm formers was 74.7%. The combined prevalence of phylogenetic Groups A, B1, B2, and D (s) were reported at 19.6%, 11%, 50.7%, and 20.5%, respectively. The most common virulence genes reported worldwide were fimA, ecpA, and fimH, with a combined prevalence of 90.3%, 86.6%, and 64.9%, respectively. The pooled prevalence of biofilm formation in UPEC isolates with phylogenetic Groups A, B1, B2, D, C, and F<br />were 12.4%, 8.7%, 33.7%, 12.4%, 2.6%, and 2.65%, respectively. Several studies showed a correlation between biofilm production and virulence genes, or phylogenetic groups.</p><p>Conclusion: Regarding data obtained, the high level of combined biofilm formation (74.7%) and the presence of a positive correlation between biofilm production and virulence genes, or phylogenetic groups as reported by the most studies included in the present review, indicates an important role of biofilm in the persistence of UPEC in the UTI. </p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11464http://jrms.mui.ac.ir/index.php/jrms/article/download/11464/6274