Assessment of blunt splenic trauma: Which imaging scoring system is superior?

Journal of Research in Medical Sciences1735-199523320180318Assessment of blunt splenic trauma: Which imaging scoring system is superior?1077110771EN20180318--- http://jrms.mui.ac.ir/index.php/jrms/article/view/10771http://jrms.mui.ac.ir/index.php/jrms/article/download/10771/5607

Journal of Research in Medical Sciences1735-199523320180319Correlation between Vitamin D3 level and extrahepatic manifestation in chronic hepatitis type?C virus patients1076810768EN20180318Background: Chronic hepatitis type?C virus (HCV) infection is one of the most common worldwide viral disorders, which leads to various clinical complications as well as extrahepatic manifestations. Furthermore, Vitamin D3 has also been reported to have relationship with the mentioned complications. Te aim is to evaluate the correlation between Vitamin D3 level and extrahepatic manifestation in chronic HCV patients. Materials and Methods: Tis cross?sectional study has been carried out on 90 patients with chronic hepatitis C. Te level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic anifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed. Results: Most of our patients were male (92% vs. 8%). Twenty?nine percent had the insufcient amount of Vitamin D3 (21–30 ng/ml), and the remains had the Vitamin D3 level between 13–20 ng/ml. Furthermore, our assessment demonstrated that defciency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confdence interval (CI) 95%] = 8.80 [1.74–44.47], P = 0.004), vasculitis (OR [95% CI] = 11.70 [3.01–45.41], P < 0.001), arthralgia (OR [95% CI] = 20.26 [4.21–97.47], P < 0.001), myalgia (OR [95% CI] = 4.00 [1.01–17.27], P = 0.048), and glomerulonephritis (P = 0.021). Conclusions: According to our results, the extrahepatic manifestation in the patients with sufcient levels of Vitamin D3 would be less possible. In fact, it could be stated that defciency in the Vitamin D3 can have a signifcant relationship with these manifestations. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10768http://jrms.mui.ac.ir/index.php/jrms/article/download/10768/5608

Journal of Research in Medical Sciences1735-199523320180319Association between oral lichen planus and Epstein–Barr virus in Iranian patients1076910769EN20180318Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no defnite etiology for this disease. Te aim of this study was to investigate the presence of Epstein–Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Materials and Methods: Te study was carried out on a case group including 38 tissue specimens of patients with histopathological confrmation of OLP and a control group including 38 samples of healthy mucosa. All samples were examined by nested polymerase chain reaction (PCR) method to determine the DNA of EBV. Results: Twenty?two (57.9%) female samples and 16 (42.1%) male samples with OLP were randomly selected as the case group, and 20 (52.6%) female samples and 18 (47.4%) male samples with healthy mucosa as the control group. Tere was a statistically signifcant di?erence in the percentage of EBV positivity between the case (15.8%) and the control groups (P < 0.05); in the case group, three female samples (13.6%) and three male samples (18.8%) were infected with EBV; the di?erence between the genders was not statistically signifcant (P = 0.50). Conclusion: Results emphasized that EBV genome was signifcantly higher among Iranian patients with OLP so antiviral therapy might be helpful <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10769http://jrms.mui.ac.ir/index.php/jrms/article/download/10769/5610

Journal of Research in Medical Sciences1735-199523320180319Prevalence of multiple birth in Isfahan, Iran1072510725EN20171115Background: According to increasing rate of using assisted reproductive technology (ART) which result in higher rates of multiple birth and natal difculties, we aimed to determine the prevalence rate of multiple birth pregnancies. Materials and Methods: A descriptive cross?sectional study evaluating birth fles in 2009–2010 of main hospitals of Isfahan, Iran. Results: Among 31640 fles’ studies, 614 cases of multiple birth pregnancies were investigated. Te product of these pregnancies were 1286 (50.2% females) infants including 557 twins (17.6/1000), 56 triplets (1.8/1000), and one case of quadruple (0.03/1000). Infants weigh <2500 g were 84.9% of all. Mothers had a mean age of 27.9 ± 4.9 which 30.4% of them had a positive history of using ART. Discussion: Te prevalence of multiple birth pregnancies is growing. Te need for more mother and child care is important. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10725http://jrms.mui.ac.ir/index.php/jrms/article/download/10725/5604

Journal of Research in Medical Sciences1735-199523320180318Magnetic resonance imaging findings in diagnosis and prognosis of Wilson disease1076710767EN20180318Wilson disease (WD) is a rare autosomal recessive disorder characterized by excessive copper deposition in the body, principally in the liver and the brain. Tere is a wide spectrum of clinical presentations, but the most signifcant and basic symptoms of the diseasecan be divided into hepatic, neurologic, and psychiatric manifestations. Magnetic resonance imaging (MRI) provides more detailedanatomical information than computed tomography of the brain, especially of the structure of the basal ganglia and brain stem. Inthis review, we want to evaluate the correlation between MRI fndings and clinical features of WD. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10767http://jrms.mui.ac.ir/index.php/jrms/article/download/10767/5611

Journal of Research in Medical Sciences1735-199523320180319Plant toxins and acute medicinal plant poisoning in children: A systematic literature review1077010770EN1, 2, 1, 1, 2,3,20180318For many years, medicinal plants and herbal therapy have been widely used in di?erent societies for the treatment of various diseases. Besides their therapeutic potency, some of the medicinal plants have strong toxicity in human, especially in children and elderly. Despite common beliefs that natural products are safe, there have been few reports on their toxicities. In the present study, we aimed to systematically review the literature wherein acute plant poisoning and herbal intoxication have been reported in pediatric patients. After literature search and selection of the appropriate documents, the desired data were extracted and described qualitatively. A total of 127 articles with overall 1453 intoxicated cases were collected. Te results of this study showed that some medicinal plants can cause acute poisoning and complications such as hepatic and renal failure in children. Te fndings of this survey showed that acute plant poisoning can be life?threatening in children, and since a single?ingested dose of toxic plants can cause acute poisoning, parents should be aware of these toxic e?ects and compare the side e?ects of self?medication with its potential benefts. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10770http://jrms.mui.ac.ir/index.php/jrms/article/download/10770/5605

Journal of Research in Medical Sciences1735-199523320180319Chronic obstructive pulmonary disease: MicroRNAs and exosomes as new diagnostic and therapeutic biomarkers1077410774EN20180318Chronic obstructive pulmonary disease (COPD) is known as a progressive lung disease and the fourth leading cause of death worldwide. Despite valuable e?orts, there is still no accurate diagnostic and prognostic tool for COPD. Hence, it seems that fnding new biomarkers could contribute to provide better therapeutic platforms for COPD patients. Among various biomarkers, microRNAs (miRNAs) have emerged as new biomarkers for the prognosis and diagnosis of patients with COPD. It has been shown that deregulation of miRNAs targeting a variety of cellular and molecular pathways such as Notch, Wnt, hypoxia?inducible factor?1?, transforming growth factor, Kras, and Smad could be involved in COPD pathogenesis. Multiple lines of evidence have indicated that extracellular vesicles such as exosomes could carry a variety of cargos (i.e., mRNAs, miRNAs, and roteins) which transfer various cellular and molecular signals to recipient cells. Here, we summarized various miRNAs which could be applied as diagnostic and prognostic biomarkers in the treatment of patients with COPD. Moreover, we highlighted the role of extracellular vesicles containing miRNAs as diagnostic and prognostic biomarkers in COPD patients. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10774http://jrms.mui.ac.ir/index.php/jrms/article/download/10774/5609

Journal of Research in Medical Sciences1735-199523320180403Misdiagnosis of spider bite in a 3?year?old child1077510775EN20180403Abdominal pain is a common complaint among children with a vast di?erential diagnosis. Hip pain is also a nonspecifc sign. Here, we present a case of a 3?year?old boy with a complaint of abdominal pain and pain in both hips, much on the right one. After evaluations, the diagnosis was a spider bite. <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10775http://jrms.mui.ac.ir/index.php/jrms/article/download/10775/5606

Journal of Research in Medical Sciences1735-199523320180319Methylenetetrahydrofo late reductase C677T polymorphism and schizophrenia: Effect of molecular change1077210772EN20180318---http://jrms.mui.ac.ir/index.php/jrms/article/view/10772http://jrms.mui.ac.ir/index.php/jrms/article/download/10772/5612

Journal of Research in Medical Sciences1735-199523320180319Responding to the challenge of antibiotic resistance: World Health Organization1077310773EN20180318---http://jrms.mui.ac.ir/index.php/jrms/article/view/10773http://jrms.mui.ac.ir/index.php/jrms/article/download/10773/5613